abstract：:Workers experience large interindividual variability in exposure and biological response following exposure to chemicals. Quantitative methods to investigate occupational exposures and their relationship with biomarker levels, toxicokinetics of chemicals, and gene-environment interactions in disease development can be...

journal_title：Progress in molecular biology and translational science

authors： Flack S,Nylander-French LA

更新日期：2012-01-01 00:00:00

abstract：:DNA damage signaling and checkpoint control pathways are among the most commonly mutated networks in human tumors. Emerging data suggest that synthetic lethal interactions between mutated oncogenes or tumor suppressor genes with molecules involved in the DNA damage response and DNA repair pathways can be therapeutical...

journal_title：Progress in molecular biology and translational science

authors： Morandell S,Yaffe MB

更新日期：2012-01-01 00:00:00

abstract：:Single-molecule approaches permit an unrivalled view of how complex systems operate and have recently been used to understand DNA-protein interactions. These tools have enabled advances in a particularly challenging problem, the search for damaged sites on DNA. DNA repair proteins are present at the level of just a fe...

journal_title：Progress in molecular biology and translational science

authors： Kad NM,Van Houten B

更新日期：2012-01-01 00:00:00

abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...

journal_title：Progress in molecular biology and translational science

authors： Dunn EF,Connor JH

更新日期：2012-01-01 00:00:00

abstract：:Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or autosomal-recessive forms of Parkinson's disease (PD), the second most common neurodegenerative disorder. Studies on the structural and functional properties of the corresponding gene products have provided significant insights into t...

journal_title：Progress in molecular biology and translational science

authors： Rochet JC,Hay BA,Guo M

更新日期：2012-01-01 00:00:00

abstract：:The Wnt family of secreted glycoproteins participates in a wide array of biological processes, including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis, hypertrophy, and aging. The canonical Wnt signaling primarily utilizes β-catenin-mediated activation of transcription, while the...

journal_title：Progress in molecular biology and translational science

authors： Flaherty MP,Kamerzell TJ,Dawn B

更新日期：2012-01-01 00:00:00

abstract：:Immunoproteasomes contain replacements for the three catalytic subunits of standard proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that lead to elevated production of immunoproteasomes. Immune system cells, especially antigen-presenting cells, express a higher basal level of imm...

journal_title：Progress in molecular biology and translational science

authors： Ferrington DA,Gregerson DS

更新日期：2012-01-01 00:00:00

abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...

journal_title：Progress in molecular biology and translational science

authors： Cook T,Zelhof A,Mishra M,Nie J

更新日期：2011-01-01 00:00:00

abstract：:Genomic imprinting is the phenomenon where the expression of a locus differs between the maternally and paternally inherited alleles. Typically, this manifests as transcriptional silencing of one of the alleles, although many genes are imprinted in a tissue- or isoform-specific manner. Diseases associated with imprint...

journal_title：Progress in molecular biology and translational science

authors： Wilkins JF,Úbeda F

更新日期：2011-01-01 00:00:00

abstract：:In eukaryotes, methylation of nucleosomal histones and other nuclear proteins is a central aspect of chromatin structure and dynamics. The past 15 years have seen an enormous advance in our understanding of the biochemistry of these modifications, and of their role in establishing the epigenetic code. We provide a syn...

journal_title：Progress in molecular biology and translational science

authors： Aravind L,Abhiman S,Iyer LM

更新日期：2011-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutic...

journal_title：Progress in molecular biology and translational science

authors： Corbo CP,Alonso Adel C

更新日期：2011-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...

journal_title：Progress in molecular biology and translational science

authors： Roberts AP,Lewis AP,Jopling CL

更新日期：2011-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:Carbon nanotubes (CNTs) are cylinder-shaped allotropic forms of carbon, most widely produced under chemical vapor deposition. They possess astounding chemical, electronic, mechanical, and optical properties. Being among the most promising materials in nanotechnology, they are also likely to revolutionize medicine. Amo...

journal_title：Progress in molecular biology and translational science

authors： Gomez-Gualdrón DA,Burgos JC,Yu J,Balbuena PB

更新日期：2011-01-01 00:00:00

abstract：:Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of...

journal_title：Progress in molecular biology and translational science

authors： Lane PJ,McConnell FM,Withers D,Gaspal F,Saini M,Anderson G

更新日期：2010-01-01 00:00:00

abstract：:Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological systems. Many clinically used drugs target GPCRs directly or target molecules involved in GPCR signaling. As an alternative to targeting receptors directly, one could modulate signaling cascades downstream of receptor activatio...

journal_title：Progress in molecular biology and translational science

authors： Sjögren B,Blazer LL,Neubig RR

更新日期：2010-01-01 00:00:00

abstract：:The etiology of obesity is multifactorial, involving complex interactions among the genetic makeup, neuroendocrine status, fetal programming, and different unhealthy environmental factors, such as sedentarism or inadequate dietary habits. Among the different mechanisms causing obesity, epigenetics, defined as the stud...

journal_title：Progress in molecular biology and translational science

authors： Campión J,Milagro F,Martínez JA

更新日期：2010-01-01 00:00:00

abstract：:Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may b...

journal_title：Progress in molecular biology and translational science

authors： Zhang X,Li JP

更新日期：2010-01-01 00:00:00

abstract：:Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic dev...

journal_title：Progress in molecular biology and translational science

authors： Ringvall M,Kjellén L

更新日期：2010-01-01 00:00:00

abstract：:A metaplastic change where normal squamous mucosa of the esophagus is replaced by columnar mucosa is considered an adaptive process to withstand the chronic gastroesophageal reflux injury. However, this phenotypic switch in the esophageal mucosa is associated with an increased propensity to undergo neoplastic transfor...

journal_title：Progress in molecular biology and translational science

authors： Singh A,Demars C,Buttar NS

更新日期：2010-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...

journal_title：Progress in molecular biology and translational science

authors： Hayes DF,Smerage JB

更新日期：2010-01-01 00:00:00

abstract：:The liver is the largest glandular organ in the body and plays a central role in controlling metabolism. During hepatogenesis, complex developmental processes must generate an array of cell types that are spatially arranged to generate a hepatic architecture that is essential to support liver function. The processes t...

journal_title：Progress in molecular biology and translational science

authors： Nagaoka M,Duncan SA

更新日期：2010-01-01 00:00:00

abstract：:Escherichia coli contains a large number of suicide or toxin genes, whose expression leads to cell growth arrest and eventual cell death. One such toxin, MazF, is an ACA-specific endoribonuclease, termed "mRNA interferase."E. coli contains other mRNA interferases with different sequence specificities, which are consid...

journal_title：Progress in molecular biology and translational science

authors： Yamaguchi Y,Inouye M

更新日期：2009-01-01 00:00:00

abstract：:Bacteriophage T4 is the archetype of virulent phage. It has evolved very efficient strategies to subvert host functions to its benefit and to impose the expression of its genome. T4 utilizes a combination of host and phage-encoded RNases and factors to degrade its mRNAs in a stage-dependent manner. The host endonuclea...

journal_title：Progress in molecular biology and translational science

authors： Uzan M

更新日期：2009-01-01 00:00:00

abstract：:Ribosomal protein S6 kinase (S6K) has been implicated in the phosphorylation of multiple substrates and is subject to activation by a wide variety of signals that converge at mammalian target of rapamycin (mTOR). In the course of the search for its physiological role, it was proposed that S6K activation and ribosomal ...

journal_title：Progress in molecular biology and translational science

authors： Meyuhas O,Dreazen A

更新日期：2009-01-01 00:00:00

abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...

journal_title：Progress in molecular biology and translational science

authors： Terzi D,Stergiou E,King SL,Zachariou V

更新日期：2009-01-01 00:00:00

abstract：:The worldwide epidemic of metabolic disease indicates that a better understanding of the pathways contributing to the pathogenesis of this constellation of diseases need to be determined. Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiatio...

journal_title：Progress in molecular biology and translational science

authors： Huang HJ,Schulman IG

更新日期：2009-01-01 00:00:00